Barack Obama has seized command of the race for the White House.
The Illinois senator has beaten John McCain in Ohio and is building a near insurmountable Electoral College advantage as he bids to become the first black president.
Fellow Democrats are gaining strength in both houses of Congress.
Obama's Ohio victory denied McCain particularly precious territory. No Republican has ever won the presidency without the state.
THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.
WASHINGTON (AP) - Barack Obama built a formidable lead in his bid to become the first black president Tuesday night, pushing ahead of John McCain in a nation clamoring for change. Fellow Democrats took four Senate seats from Republicans, and reached for more.
Obama gained precious ground in Pennsylvania, winning the state's 21 electoral votes and depriving McCain of the Democratic-leaning state where he had tried hardest to break through. Obama also swept through territory typically friendly to Democrats in the East and Midwest.
McCain countered in the safest of Republican states.
That left the battlegrounds to settle the race: Florida, Ohio, Virginia, Colorado and more. Most were customarily Republican, but Obama spent millions hoping to peel away enough to make him the 44th president, and his triumph in Pennsylvania left the Republican with scant room for error.
"May God bless whoever wins tonight," President Bush told dinner guests at the White House, according to spokeswoman Dana Perino.
A jubilant crowd of thousands gathered in Grant Park in downtown Chicago on an unseasonably mild night, confident it would be Obama. They reacted each time Obama was announced the winner in another state - and the cheers were particularly loud when Pennsylvania fell.
Interviews with voters suggested that almost six in 10 women were backing Obama nationwide, and men leaned his way by a narrow margin. Just over half of whites supported McCain, giving him a slim advantage in a group that Bush carried overwhelmingly in 2004.
The results of The Associated Press survey were based on a preliminary partial sample of nearly 10,000 voters in Election Day polls and in telephone interviews over the past week for early voters.
The same survey showed the economy was by far the top Election Day issue. Six in 10 voters said so, and none of the other top issues - energy, Iraq, terrorism and health care - was picked by more than one in 10.
The AP made its calls of individual states based on surveys of voters as they left the polls.
Obama led in electoral votes with 175 of the 270 needed to win the White House. McCain had 61.
The Democrat's states included Wisconsin, Michigan, New York, Rhode Island, Minnesota, Pennsylvania, New Hampshire, Vermont, Connecticut, Delaware, Illinois, Maine, Massachusetts, Maryland and New Jersey, as well as the District of Columbia.
McCain had Arkansas, Kansas, Kentucky, Tennessee, Oklahoma, Wyoming, Alabama, South Carolina and North Dakota.
The nationwide popular vote was remarkably close. Totals from 13 percent of the nation's precincts showed Obama with 49.9 percent and McCain with 49.2.
Democrats celebrated Senate successes in Virginia, where former Gov. Mark Warner won an open seat, in New Mexico, where Rep. Tom Udall did likewise. In New Hampshire, former Gov., Jeanne Shaheen defeated Republican Sen. John Sununu in a rematch of their 2002 race, and North Carolina Sen. Elizabeth Dole fell to Democrat Kay Hagan.
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